What causes Parkinson's disease is still unknown today,
however with the development of an animal model of Parkinson’s disease much is
learned about the disease (Knierim, 2013). Knierim (2013), "Parkinson’s
disease results from the death of dopaminergic neurons in the substantia nigra
pars compacta" (para. 14). Which, is the cause of the damage to the motor
pathways in an individual with Parkinson's disease. When the substantia nigra
neurons are lost this puts a hold on or stops the output of motor cortex, which
inhibits voluntary motor commands from descending to the spinal cord and brain
stem (Knierim, 2013). Substantia nigra activity excites the direct pathway and
inhibits the indirect pathway (Knierim, 2013). The direct pathway excites the
motor cortex and the indirect pathway inhibits motor cortex. Which, disrupts
the inhibition and excitation balance in the basal ganglia and the excitation
of motor cortex is reduced. The resulting symptoms that occur include resting
tremors, and severe bradykinesia or akinesia. In the advanced cases of
individuals with Parkinson's disease there is difficulty initiating movements.
However, what may still be normal are involuntary, reflexive movements.
Reference
Knierim, J. (2013). Neuroscience Online. Retrieved from http://neuroscience.uth.tmc.edu/s3/chapter06.html
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